Connecticut Epidemiologist Newsletter   •   January 2022   •   Volume 41, No.2

Reportable Laboratory Findings - 2022

The director of a clinical laboratory must report laboratory evidence suggestive of reportable diseases using the Laboratory Report of Significant Findings form (OL-15C) when Electronic Laboratory Surveillance has not yet been established. The form can be found on the DPH ”Forms” webpage in a fillable PDF or can be ordered by calling 860-509-7994. Mailed reports must be sent in envelopes marked “CONFIDENTIAL.” 

Possible Indicators of Bioterrorism
Persons Required to Report
Important Notice

Anaplasma phagocytophilum by PCR only
Babesia  • IFA  • IgM (titer)  • IgG (titer)  • Blood smear  • PCR  • Other (specify) 
• microti  • divergens  • duncani  • Unspeciated
Bordetella pertussis (titer)  • Culture (1)  • Non-pertussis Bordetella (1) (specify)  • DFA  • PCR
Borrelia burgdorferi (2)
Borrelia miyamotoi
California group virus (3) (specify species)
Campylobacter (specify species)  • Culture  • PCR  • EIA (3
Candida auris [report samples from all sites] (1)
Candida (specify species) [blood isolates only] (1,3)
Carbapenem-resistant Acinetobacter baumannii (CRAB) (1,4)
Carbapenem-resistant Enterobacteriaceae (CRE) (specify Genus & species) (1,3,4)
Carboxyhemoglobin > 5% (specify % COHb) (2
Chikungunya virus
Chlamydia trachomatis (specify test type)
Clostridium difficile (5)
Corynebacterium diphtheria (1)
Cryptosporidium (specify species) • PCR  • DFA  • EIA  • Microscopy  • Other (specify) (3) Cyclospora (specify species)  • PCR  • Microscopy  • Other (specify) (3) Dengue virus
Eastern equine encephalitis virus
Ehrlichia chaffeensis • PCR  • IgG titers ≥1:128 only  • Culture
Enterotoxigenic Escherichia coli (ETEC)  • Culture  • PCR   
Escherichia coli O157 (1)  • Culture  • PCR   
Giardia (specify species) (3)
Group A Streptococcus, invasive  • Culture  • Other (specify) (1,4)
Group B Streptococcus, invasive  • Culture  • Other (specify) (1,4)
Haemophilus ducreyi
Haemophilus influenzae, invasive  • Culture  • Other (specify) (1,4)
Hepatitis A virus (HAV) • IgM anti-HAV (7) • NAAT Positive (6) • ALT  • Total Bilirubin  • Not Done
Hepatitis B  • HBsAg • Positive  • Negative (7)  • IgM anti-HBc  • HBeAg (2)  • HBV DNA (2)
anti-HBs (7)  • Positive (specify titer)  • Negative
Hepatitis C virus (HCV) specify • Antibody  • PCR/NAAT/RNA  • Genotype (8
Herpes simplex virus (infants < 60 days of age)  • Culture  • PCR  • IFA  • Ag detection
HIV Related Testing (report only to the State) (9)
Detectable Screen (IA)
Antibody Confirmation (WB/IFA/Type-diff) (9)
HIV 1  Positive   Neg/IndHIV 2  • Positive  • Neg/Ind
HIV NAAT (or qualitative RNA)  • Detectable  • Not Detectable
HIV Viral Load (all results) (9) (specify copies/mL)
HIV genotype (9)
CD4 count: (specify cells/uL; %) (9)
HPV (report only to the State) (10) Biopsy proven • CIN 2 • CIN 3 • AIS or their equivalent (specify)      
Influenza virus: (report only to State)  • Rapid antigen (2)  • RT-PCR 
• T
ype A  • Type B  • Type Unknown  • Subtype (specify)
Lead poisoning (blood lead >10 µg/dL <48 hrs; 0-9 µg/dL monthly) 
• Finger stick level µg/dL  • Venous level µg/dL (
Legionella (specify species)  • Culture  • DFA  • Ag positive  • Four-fold serologic change (specify titers) (1)
Listeria monocytogenes (1)  • Culture  • PCR
Mercury poisoning, specify  • Urine > 35 µg/g creatinine  • Blood > 15 µg/L
Monkeypox virus  • PCR • IgM anti-MPXV • Sequencing
Orthopoxvirus  • PCR • ICH • Sequencing
Non-variola orthopoxvirus •PCR
Mumps virus (12) (specify titer)  • PCR
Mycobacterium leprae
Mycobacterium tuberculosis Related Testing (1)
AFB Smear  • Positive  • Negative
If positive • Rare  • Few  • Numerous
NAAT  • Positive  • Negative • Indeterminate
Culture  • Mycobacterium tuberculosis  • Non-TB mycobacterium. (specify M.)
Neisseria gonorrhoeae (specify test type)
Neisseria meningitidis, invasive (1,4)  • Culture  • Other (specify)
Neonatal bacterial sepsis (specify species) (3,13)
Plasmodium (specify species) (1,3)
Powassan virus
Rabies virus
Rickettsia rickettsia  • PCR  • IgG titers ≥1:128 only  • Culture
Respiratory syncytial virus (2)
Rubella virus (specify titer) (12)
Rubeola virus (specify titer) (12• PCR
St. Louis encephalitis virus
Salmonella (specify serogroup & type) (1,3)   • Culture  • PCR
SARS-CoV (1) • IgM/IgG  • PCR (specify specimen)  • Other (specify)
SARS-CoV2  • PCR  • Antigen  • Positive  • Negative
Shiga toxin (1) • Stx1  • Stx2  • Type Unknown  • PCR  • EIA
Shigella (specify serogroup & species) (1,3 • Culture  • PCR
Staphylococcus aureus, invasive (4)  • Culture  • Other (specify)
• methicillin-resistant  • methicillin-sensitive
Staphylococcus aureus, vancomycin  MIC > 4 µg/mL (1)
MIC to vancomycin(specify) µg/mL
Staphylococcus epidermidis, vancomycin  MIC 32 µg/mL (1)
MIC to vancomycin (specify) µg/mL
Streptococcus pneumoniae  • Culture (1,4) • Urine antigen  • Other (specify) (4)
Treponema pallidum  • RPR (specify titer)  • FTA  • EIA  • VDRL (specify titer)  • TPPA
Varicella-zoster virus, acute  • Culture  • PCR  • DFA  • Other (specify)
Vibrio (specify species) (1,3)  • Culture  • PCR
West Nile virus
Yellow fever virus
Yersinia, not pestis (specify species) (1,3)  • Culture  • PCR
Zika virus

Bioterrorism at first clinical suspicion (14)

Bacillus anthracis (1)

Brucella (specify species) (1)

Burkholderia mallei (1)

Burkholderia pseudomallei (1)

Clostridium botulinum

Coxiella burnetii

Francisella tularensis

Ricin (1)

Staphylococcus aureus - enterotoxin B

Variola virus (1)

Venezuelan equine encephalitis virus

Viral agents of hemorrhagic fevers (1)

Yersinia pestis (1)


1. Send isolate/specimen to DPH Laboratory. Send laboratory report (electronic or paper) on first identification of an organism. For CRE/CRAB, send laboratory report if carbapenem resistance is suggested by laboratory antimicrobial testing. For GBS, send isolate for cases <1 year of age. For SalmonellaShigellaVibrio, and Yersinia (not pestis) tested by non-culture methods, send isolate if available; send stool specimen if no isolate available. For Shiga toxin-related disease, send positive broth or stool specimen.
2. Only laboratories with electronic file reporting are required to report positive results.
3. Specify species/serogroup/serotype.
4. Sterile site: sterile fluids (blood, CSF, pericardial, pleural, peritoneal, joint, or vitreous), bone, internal body site (lymph node, brain, heart, liver, spleen, kidney, pancreas, or ovary), or other normally sterile site including muscle. For CRE and CRAB, also include urine or sputum; for CRAB also include wounds.
5. Upon request from the DPH, report all C. difficile positive stool samples.
6. Report peak ALT and Total Bilirubin results if conducted within one week of HAV positive test, if available. Otherwise, check “Not Done”.
7. Negative HBsAg and all anti-HBs results only reportable for children < 2 years old.
8. Report positive Antibody, and all RNA and Genotype results. Negative RNA results only reportable by electronic reporting.
9. Report all HIV antibody, antigen, viral load, and qualitative NAAT results. HIV genotype (DNA sequence) and all CD4 results are only reportable by electronic file.
10. Upon request from the DPH, send fixed tissue from the diagnostic specimen for HPV typing.
11. Report results > 10 µg/dL within 48 hours to the Local Health Department and DPH; submit ALL lead results at least monthly to DPH only.
12. Report all IgM positive titers, only report IgG titers considered significant by laboratory performing the test.
13. Report all bacterial isolates from blood or CSF from infants < 72 hours of age.
14. Call the DPH, weekdays 860-509-7994; evenings, weekends, and holidays 860-509-8000.

Persons Required to Report Reportable Laboratory Findings

The director of a laboratory that receives a primary specimen or sample, which yields a reportable laboratory finding, shall be responsible for reporting such findings within 48 hours to the local director of health of the town in which the affected person normally resides. In the absence of such information, the reports should go to the town from which the specimen originated and to the Department of Public Health. Reports must include name, address, contact phone number, date of birth, race, ethnicity, gender, and occupation of patient.


Important Notice


The Laboratory Report of Significant Findings Form OL-15C can be used by staff of clinical laboratories to report evidence suggestive of reportable diseases when Electronic Laboratory Reporting has not been established. Reporting forms can be found at: ( or by calling 860-509-7994. Please follow these guidelines when submitting written reports:


  • Forms must be complete and include name, address, and phone number of person reporting and healthcare provider, infectious agent, test method, date of onset of illness, and name, address, date of birth, race, ethnicity, gender, and occupation of patient.
  • Send the white copy of completed form to DPH via fax (860-920-3131), or mail to: Connecticut Department of Public Health, 410 Capitol Ave., MS#11FDS, P.O. Box 340308, Hartford, CT 06134-0308. Mark envelope with “CONFIDENTIAL”.
  • Unless otherwise noted, send the yellow copy of the completed report to the Director of Health of the patient’s town of residence.
  • Keep the pink copy in the patient’s medical record.


This page last updated 07/11/2022.