Connecticut State Department of Public Health


Connecticut Stem Cell Research Grants-in-Aid Program

 

The Connecticut Stem Cell Research Grants-in-Aid Program was established by the Connecticut General Assembly in June 2005 when it passed Connecticut General Statutes §19a-32d through §19a-32g. This legislation appropriates $20 million dollars to support embryonic and human adult stem cell research through June 30, 2007.  In addition, for each of the fiscal years ending June 30, 2008 through June 30, 2015, the legislation specifies that an additional $10 million dollars should be disbursed to support additional research.  In total, at least $100 million in public support will be available over the next ten years for stem cell research.    

Lay Summary Example
 

Below is an example of a lay summary excerpt from a technical report required of all grantees that meets the expectations of the Stem Cell Research Advisory Committee:

5.  Detailed lay language summary:

There is great promise in embryonic stem cell-based therapies to treat a variety of neurological disorders. It is key that we understand how the transplanted cells may interact with the host brain to guarantee the safety of this approach. We observe that robust transplants of embryonic stem cell-derived neural progenitors in the hippocampus are richly vascularized, associated with multiple blood vessels. In addition, the transplanted cells can migrate on these blood vessels some distance away from the initial transplant site. We are now studying how interactions with the blood vessels may nurture the transplant and support its successful integration into the host. We are also examining the factors that might promote or inhibit the migration of transplanted cells on the surface of existing blood vessels. This interaction could be used to target grafted cells to a specific site. Alternatively this could be a dangerous process we would like to block, as it could lead to cells present in undesirable places.

Significance of recent findings: When embryonic stem cell-derived neural progenitors are transplanted to the central nervous system, the general expectation is that they will remain where transplanted, or perhaps migrate short distances. Our observation that these cells can migrate on blood vessels long distances sets up a red flag: cells may well end up a great distance from where they were intended to be.  By understanding the molecular basis for this migration, we hope to be able to control it, specifically inhibit it when the desire is to keep a transplant in place. Alternatively, it may be desirable to use this blood vessel highway to target cells to specific distant sites.

 

   

Frequently Asked Questions

How did Connecticut’s Stem Cell Research Program come about?  

The Connecticut Stem Cell Research Grant Project is the direct result of legislation passed by the General Assembly in 2005 (Connecticut General Statutes §19a-32d through §19a-32g.). This legislation provides public funding in support of stem cell research on embryonic and human adult stem cells. This legislation also bans the cloning of human beings in Connecticut.

Back to Questions

What kinds of research will be eligible for funding?  

The Stem Cell Research Fund supports embryonic and human adult stem cell research, including basic research to determine the properties of stem cells.

 Back to Questions

Where is the money coming from for this research?  

Stem cell research funds come from the Stem Cell Research Fund. This Fund will receive a total of $100 million dollars of state money over ten years. The General Assembly had set aside $20 million of state money for the purpose of stem cell research through June 2007. An additional $10 million dollars a year over the subsequent eight years will come from the Connecticut Tobacco Settlement Fund.  The Stem Cell Research Fund may also contain any funds received from any public or private contributions, gifts, grants, donations or bequests.  

Back to Questions

Who oversees the Stem Cell Research Fund?  

The Commissioner of the State Department of Public Health (DPH) may make grants-in-aid from the fund.  The Connecticut Stem Cell Research Advisory Committee (Advisory Committee), a legislatively appointed committee established by Connecticut General Statutes §19a-32d through §19a-32g, directs the Commissioner with respect to the awarding of grants-in-aid, and develops the stem cell research application process.  The Stem Cell Research Advisory Committee is also required to keep the Governor and the General Assembly apprised of the current status of stem cell research in Connecticut through annual reports commencing June 2007.

The legislation further established a Connecticut Stem Cell Research Peer Review Committee (Peer Review Committee) to review all applications with respect to the scientific and ethical merits and to make recommendations to the Advisory Committee and the Commissioner of DPH.

Back to Questions

How are the members of the Stem Cell Research Advisory Committee determined?  

The Stem Cell Research Advisory Committee is made up of 17 members.  By statute, the Advisory Committee is chaired by the Commissioner of the Connecticut Department of Public Health (DPH). Other members of the committee are appointed by the Governor and by various leaders of the General Assembly from the fields of stem cell research, stem cell investigation, bioethics, embryology, genetics, cellular biology and business. Committee members commit to a two-year or four-year term of service.  

Back to Questions

Who evaluates the merits of the grant applications and decides how the grants are distributed?  

The Stem Cell Research Peer Review Committee reviews all grant applications for scientific and ethical merit, guided by the National Academies Guidelines for Human Embryonic Stem Cell Research. The Stem Cell Research Peer Review Committee makes its recommendations on grants to the Stem Cell Research Advisory Committee for consideration.  The members of the Stem Cell Peer Review Committee must have demonstrated and practical knowledge, understanding and experience of the ethical and scientific implications of embryonic and adult stem cell research. The DPH Commissioner appoints all committee members for either two or four-year terms. The Stem Cell Research Advisory Committee directs the Commissioner of the Department of Public Health with respect to the awarding of grants-in-aid.  

Back to Questions

Who may apply for the stem cell research grants?  

Any non-profit, tax-exempt academic institution of higher education, any hospital that conducts biomedical research or any entity that conducts biomedical research or embryonic or human adult stem cell research may apply for grants from the Connecticut Stem Cell Research Fund.  

Back to Questions

What efforts are being made to assure the people of the state of Connecticut that all committee dealings and any research are ethically conducted?

The State of Connecticut is committed to implementing the Stem Cell Research Program according to the highest ethical and scientific standards, and committed to conducting all business activities in a transparent and consumer friendly manner.  Meetings of the committee where decisions are being made will comply with Freedom of Information Act requirements for public meetings and public records.  Proceedings of all scheduled meetings of the Advisory Board will be transcribed and made available to the public, and when possible, meetings will be televised via local public access television.

Members of the Stem Cell Research Advisory Committee are considered to be public officials and are subject to state ethics laws, which require full accountability and transparency.  Both the Peer Review and Advisory Committees are responsible for overseeing the standards of research funded from this grant program.  Reports on scientific progress are required of grant recipients.  Annual financial disclosures are required for all members of the Stem Cell Research Advisory Committee.  

Back to Questions

Who else is involved with overseeing this project?  

The State of Connecticut Department of Public Health, working in conjunction with the legislatively mandated Advisory and Peer Review Committees, is responsible for the overall implementation of the stem cell legislation.  Within the DPH, the Office of Research and Development is the organizational unit tasked with managing the stem cell research project components.

In addition, the stem cell legislation names Connecticut Innovations as the administrative staff of the Stem Cell Research Advisory Committee, assisting the Advisory Committee in developing and implementing the application process, including application reviews and execution of agreements.  

 Back to Questions

What is the timeline for the application process?

The Advisory Committee developed and issued the first Request for Proposals on May 10, 2006.  As of the July 10, 2006 deadline, 70 applications for public funding were received.  Applications were made available for peer review on August 4, 2006. On November 21, 2006, the Stem Cell Research Advisory Committee awarded almost $19.8 million for 21 stem cell research proposals.

The second Request for Proposals was issued on July 25, 2007.  As of the November 1, 2007 deadline, 94 applications for public funding were received.  The Peer Review Committee completed their review and reported by teleconference on March 5, 2008.  On April 1, 2008, the SCRAC awarded $9.84 million for 22 stem cell research projects.

The third Request for Proposals was issued on September 24, 2008.  As of the December 8, 2008 deadline, 77 applications for public funding were received.  The Peer Review Committee completed their review and reported by teleconference on March 17, 2009.  On March 31, 2009, the SCRAC awarded $9.8 million for 24 stem cell research projects.

Back to Questions

Which grant applications received funding in 2006?

  • An Integrated Approach to Neural Differentiation of Human Embryonic Stem Cells, Yale University, Michael P. Snyder, Principal Investigator, $3,815,476.72

  • Directing hES Derived Progenitor Cells into Musculoskeletal Lineages, University of Connecticut Health Center and University of Connecticut, David W. Rowe, M. D., Principal Investigator, $3,520,000

  • Human Embryonic Stem Cell Core Facility at Yale Stem Cell Center, Yale University, Haifan Lin, Principal Investigator, $2,500,000

  • Human ES Cell Core At University of Connecticut and Wesleyan University, University of Connecticut Health Center, Ren-He Xu, Principal Investigator, $2,500,000

  • DsRNA and Epigenetic Regulation in Embryonic Stem Cells, University of Connecticut Health Center, Gordon G. Carmichael, $880,000.

  • Alternative Splicing in Human Embryonic Stem Cells, University of Connecticut Health Center, Brenton R. Graveley, Principal Investigator, $880,000

  • SMAD4-based ChIP-chip Analysis to Screen Target Genes of BMP and TGF Signaling in Human ES Cells, University of Connecticut Health Center, Ren-He Xu, Principal Investigator, $880,000

  • Directing Production and Functional Integration of Embryonic Stem Cell-Derived Neural Stem Cells, Wesleyan University, Laura B. Grabel, Principal Investigator, $878,348.24

  • Role of the Leukemia Gene MKL in Developmental Hematopoiesis Using hES Cells, Yale University, Diane Krause, Principal Investigator, $856,653.72

  • Migration and Integration of Embryonic Stem Cell Derived Neurons into Cerebral Cortex, University of Connecticut, Joseph LoTurco, Principal Investigator, $561,631.84

  • Optimizing Axonal Regeneration Using a Polymer Implant Containing hESC-derived Glia, University of Connecticut, Akiko Nishiyama, $529,871.76

  • Development of Efficient Methods for Reproducible and Inducible Transgene Expression in Human Embryonic Stem Cells, University of Connecticut Health Center, James Li, Principal Investigator, $200,000

  • Pragmatic Assessment of Epigenetic Drift in Human ES Cell Lines, University of Connecticut, Theodore Rasmussen, Ph.D., Principal Investigator, $200,000

  • Cell Cycle and Nuclear Reprogramming by Somatic Cell Fusion, University of Connecticut Health Center, Winfried Krueger, Principal Investigator, $200,000

  • Function of the Fragile X Mental Retardation Protein in Early Human Neural Development, Yale University, Yingqun Joan Huang, Principal Investigator, $200,000

  • Quantitative Analysis of Molecular Transport and Population Kinetics of Stem Cell Cultivation in a Microfluidic System, University of Connecticut, Tai-His Fan, Principal Investigator, $200,000

  • Embryonic Stem Cell as a Universal Cancer Vaccine, University of Connecticut Health Center, Bei Liu, Zihai Li, M. D., Principal Investigators, $200,000

  • Lineage Mapping of Early Human Embryonic Stem Cell Differentiation, University of Connecticut, Craig E. Nelson, $200,000

  • Directed Isolation of Neuronal Stem Cells from hESC Lines, Yale University School of Medicine, Eleni A. Markakis, Principal Investigator, $184,407

  • Magnetic Resonance Imaging of Directed Endogenous Neural Progenitor Cell Migration, Yale University School of Medicine, Erik Shapiro, Principal Investigator, $199,975

  • Generation of Insulin Producing Cells from Human Embryonic Stem Cells, University of Connecticut, Gang Xu, Principal Investigator, $200,000

Back to Questions

Which grant applications received funding in 2008? 

  • Maintaining and Enhancing the Human Embryonic Stem Cell Core at the Yale Stem Cell Center, Yale University Stem Cell Center, New Haven, Haifan Lin, PhD, Principal Investigator, $1,800,000.
  • Translational Studies in Monkeys of hESCs for Treatment of Parkinson’s Disease, Yale University School of Medicine, New Haven, D. Eugene Redmond, Jr., MD, Principal Investigator, $1,120,000.
  • Production and Validation of Patient-Matched Pluipotent Cells for Improved Cutaneous Repair, University of Connecticut Center of Regenerative Biology, Storrs, Theodore Rasmussen, PhD., Principal Investigator, $634,880.
  • Directed Differentiation of ESCs into Cochlear Precursors for Transplantation as Treatment of Deafness, University of Connecticut, Storrs, Ben Bahr, PhD, Principal Investigator, $500,000.
  • Synaptic Replenishment Through Embryonic Stem Cell Derived Neurons in a Transgenic Mouse Model of Alzheimer's Disease, University of Connecticut Health Center, Farmington, Nada Zecevic, MD, PhD, Principal Investigator, $499,813.
  • Tyrosone Phosphorylation Profiles Associated with Self-Renewal and Differentiation of hESC, University of Connecticut Health Center, Farmington, Bruce Mayer, PhD., Principal Investigator, $450,000.
  • Directed Differentiation of ESCs into Cochlear Precursors for Transplantation as Treatment of Deafness, University of Connecticut Health Center, Farmington, D. Kent Morest, MD, Principal Investigator, $450,000.
  • Targeting Lineage Committed Stem Cells to Damaged Intestinal Mucosa, University of Connecticut Health Center, Farmington, Daniel W. Rosenberg, PhD., Principal Investigator, $450,000.
  •  Modeling Motor Neuron Degeneration in Spinal Muscular Atrophy Using hESCs, University of Connecticut Health Center, Farmington, Xuejun Li, PhD., Principal Investigator, $450,000.
  •  Human Embryonic and Adult Stem Cell for Vascular Regeneration, Yale University School of Medicine, New Haven, Laura E. Niklason, MD, PhD, $450,000.
  • Effect of Hypoxia on Neural Stem Cells and the Function in CAN Repair, Yale University, New Haven, Flora M. Vaccarino, Principal Investigator, $449,771.40.
  • Wnt Signaling and Cardiomyocyte Differentiation from hESCs, Yale University, New Haven, Dianqing Wu, Principal Investigator, $446,818.50.
  • Flow Cytometry Core for the Study of hESC, University of Connecticut Health Center, Farmington, Hector Leonardo Aguila, PhD., Principal Investigator, $250,000.
  • Cortical neuronal protection in spinal cord injury following transplantation of dissociated neurospheres derived from human embryonic stem cells, Yale University School of Medicine, New Haven, Masanori Sasaki, MD, PhD, Principal Investigator, $200,000.
  • Molecular Control of Pluripotency in Human Embryonic Stem Cell, Yale Stem Cell Center, New Haven, Natalia Ivanova, Principal Investigator, $200,000.
  • Cytokine-induced Production of Transplantable Hematopoietic Stem Cells from Human ES Cells, University of Connecticut Health Center, Farmington, Laijun Lai, PhD, Principal Investigator, $200,000.
  • Functional Use of Embryonic Stem Cells for Kidney Repair, Yale University, New Haven, Lloyd G. Cantley, Principal Investigator, $200,000.
  • VRK-1-mediated Regulation of p53 in the Human ES Cell Cycle, Yale University, New Haven, Valerie Reinke, Principal Investigator, $200,000.
  • Definitive Hematopoitic Differentiation of hESCs under Feeder-Free and Serum-Free Conditions, Yale University, Caihong Qiu, PhD, Principal Investigator, $200,000.
  • Differentiation of hESC Lines to Neural Crest Derived Trabecular Meshwork Like Cells – Implications in Glaucoma, University of Connecticut Health Center, Farmington, Dharamainder Choudhary, PhD., Principal Investigator, $200,000.
  • The Role of the piRNA Pathway in Epigenetic Regulation of hESCs, Yale University, New Haven, Qiaoqiao Wang, PhD., Principal Investigator, $200,000.
  • Early Differentiation Markers in hESCs: Identification and Characterization of Candidates, University of Connecticut Center for Regenerative Biology, Storrs, Mark G. Carter, PhD., Principal Investigator, $200,000.
  • Regulation hESC-dervied Neural Stem Cells by Notch Signaling, Yale University, New Haven, Joshua Breunig, MD, Principal Investigator, $188,676. 

Back to Questions

Which grant applications received funding in 2009? 

·      Continuing and Enhancing the UCONN-Wesleyan Stem Cell Core, University of Connecticut Stem Cell Center, Farmington, Ren-He Xu, MD, PhD, Principal Investigator, $1,900,000.00.

·      Williams Syndrome Associated TFII-I Factor and Epigenetic Marking-Out in hES and Induced Pluripotent Stem Cells, University of Connecticut Health Center, Farmington, Dashzeveg Bayarsaihan, PhD., Principal Investigator, $500,000.00.

·      Cellular transplantation of neural progenitors derived from human embryonic stem cells to remyelinate the nonhuman primate spinal cord, Yale University, New Haven, Jeffrey Kocsis, PhD., Principal Investigator, $500,000.00.

·       Mechanisms of Stem Cell Homing to the Injured Heart, University of Connecticut Health Center, Linda Shapiro, PhD., Principal Investigator, $500,000.00.

·      Genome-wide screen to identify hESC-specific DNA transcription elements, Yale University, New Haven, Richard Sutton, MD, PhD., Principal Investigator, $500,000.00.

·      Molecular function of Lin28 in human embryonic stem cells, Yale University, New Haven, Yingqun Huang, MD, PhD., Principal Investigator, $500,000.00.

·      Therapeutic differentiation of regulatory T cells from iPS and hES for immune tolerance, University of Connecticut Health Center, Zihai Li, MD, PhD., Principal Investigator, $500,000.00.

·      Prevention of Spontaneous Differentiation and Epigenetic Compromise of Human ES and iPS Cells, University of Connecticut, Storrs, Theodore Rasmussen, PhD., Principal Investigator, $499,956.00.

·      Development of iPS cells to study craniometaphyseal dysplasia in humans, University of Connecticut Health Center, Farmington, Alex Lichtler, PhD., Principal Investigator, $500,000.00

·      piggyBac Transposon for Genetic Manipulation and Insertional Mutagenesis in Human Embryonic Stem Cells, Yale University, New Haven, Tian Xu, PhD., Principal Investigator, $500,000.00.

·      Brain Grafts of GABAergic Neuron Precursors Derived from Human and Mouse ES Cells for Treating Temporal Lobe Epilepsy, Wesleyan University, Middletown, Janice Naegele, PhD., Principal Investigator, $499,988.00.

·      MicroRNA regulation of hESC fates, Yale University, New Haven, Jun Lu, PhD., Principal Investigator, $500,000.00.

·      Molecular profiling and cell fate potential of hESC-derived early neural crest precursors, Yale University, New Haven, Martín I García-Castro, PhD., Principal Investigator, $200,000.00.

·      Neural Stem Cell Responses to Hypoxia, Yale University, New Haven, Qi Li, PhD., Principal Investigator, $200,000.00.

·      Induction and differentiation of beta cells from human embryonic stem cells, Yale University, New Haven, Kevan Herold, MD, $200,000.00.

·      Evaluation of homologous recombination in hESC and stimulation using viral proteins, University of Connecticut Health Center, Farmington, April Schumacher, PhD., Principal Investigator, $200,000.00.

·      Transcriptional control of keratinocyte differentiation in human ES cells, Yale University, New Haven, Valerie Horsley, Principal Investigator, PhD., $200,000.00.

·      Novel response to RNA editing in human embryonic stem cells, University of Connecticut Health Center, Farmington, Ling-Ling Chen, Principal Investigator, PhD.,$200,000.00.

·      A human cell culture model of Angelman syndrome for drug screening, University of Connecticut Health Center, Farmington, Stormy Chamberlain, PhD., Principal Investigator, $200,000.00.

·      Can Natural Neuromodulators Improve the Generation of Nerve Cells From Human Embryonic Stem Cells?, University of Connecticut Health Center, Farmington, Srdjan Antic, MD, Principal Investigator, $200,000.00.

·      Investigating the role of nuclear RNA quality surveillance in embryonic stem cells, Yale University, New Haven, Sandra Wolin, MD, PhD., Principal Investigator, $200,000.00.

·      The Influence of Aberrant Notch Signaling on Rb Mediated Cell Cycle Regulation in Megakaryopoiesis & Acute Megakaryoblastic Leukemia, Yale University, New Haven, Stephanie Massaro, MD, Principal Investigator, $200,000.00.

·      Derivation and Functional Characterization of Heart Cells from Human Embryonic Stem Cells, Yale University, New Haven, Yibing Qyang, PhD., Principal Investigator, $200,000.00.

·       Hybrid Peptide/RNA Molecules for Safe and Efficient Gene Silencing in Human Embryonic Stem Cells, University of Connecticut, Storrs, Yong Wang, PhD., Principal Investigator, $200,000.00.

Back to questions

______________________________________________________________________________

Which grants received funding in 2010?

·      Reconstitution of human hematopoietic system by HSCs derived from human embryonic stem cells in humanized mice, Yale University, New Haven, Richard A. Flavell, Principal Investigator, $1,000,000.00

·      Use of human embryonic stem cells and inducible pluripotent stem cells to study megakaryoblastic leukemia, Yale University, New Haven, Diane Krause, Principal Investigator, $1,000,000.00.

·      Generation of hematopoietic stem cells and T-cell progenitors from human ESCs, University of Connecticut Health Center, Farmington, Laijun Lai, $1,000,000.00.

·      Modeling Parkinson’s disease using human embryonic stem cells and patient-derived induced pluripotent stem cells, University of Connecticut Health Center, James Yuanhao Li, Principal Investigator, $992,500.00.

·      Mechanical control of neural stem cell fate, Yale University, New Haven, Angelique Bordey, Principal Investigator, $947,975.00.

·      Co-differentiation of hESC-derived retinal and retinal pigment epithelial progenitors, Yale University, New Haven, Lawrence J. Rizzolo, Principal Investigator, $832,608.00.

·      Regulations of Lin28 in Human Embryonic Stem Cell Self-renewal And Differentiation, Yale University, New Haven, Caihong Qiu, Principal Investigator, $750,000.00

·      Stem Cell Physiology and Chemistry Core, University of Connecticut Health Center, Farmington, Srdjan D. Antic, M.D., Principal Investigator, $500,000.00

·      Maturation of human embryonic stem (hES) cell-derived cardiomyocytes in vitro using 3D engineered tissue model system, Yale University, New Haven, Lee, Principal Investigator, $200,000.00.

·      The Role of Dormant Replication Origins in Ensuring Genome Integrity in Human Embryonic Stem Cells, Yale University, New Haven, XinQuan Ge, Ph.D., Principal Investigator, $200,000.00

·      Regulating Caspase Activity to Enhance Differentiation Efficiency of Human Embryonic Stem Cells, University of Connecticut Health Center, Farmington, Xiaofang Wang, Ph.D., M.D., Principal Investigator, $200,000.00.

·       Novel roles of long non-coding RNAs in human embryonic stem cells, University of Connecticut Health Center, Farmington, Li Yang, Principal Investigator, $200,000.00.

·      Molecular mechanisms of germ layer induction in human embryonic stem cells, Yale University, New Haven, Efrat Oron, Principal Investigator, $200,000.00.

·      Identification and characterization of multipotent cell populations from human adipose tissue for application in regenerative therapies, Yale University, New Haven, Matthew S. Rodeheffer, Principal Investigator, $200,000.00.

·      Efficient Gene Targeting in Human Embryonic Stem Cell via Recombineering Based Long Arm Targeting Vector, Yale University, New Haven, Chunsheng Dong, Principal Investigator, $200,000.00.

·      The role of epigenetic factor-HP1 in regulating human embryonic stem cell pluripotency and differentiation, Yale University, New Haven, Ee-Chun Cheng, Principal Investigator, $200,000.00.

·      In vivo Evaluation of Humans ES, IPS and Adult Brain Derived Neural Progenitor Cell Tranplantation and Migration Using MRI, Yale University, New Haven, Erik M.  Shapiro, PhD, Principal Investigator, $200,000.00.

·      Discovering treatments to prevent neurodegeneration in Huntington’s Disease using hESCs and patient-derived iPSCs, University of Connecticut Health Center, Farmington, Carolyn Drazinic, M.D., Ph.D., Principal Investigator, $200,000.00.

·      Generation of a novel source of iPS cells for the treatment of osteoarthritis, University of Connecticut Health Center, Farmington, Rosa M. Guzzo, Ph.D., Principal Investigator, $200,000.00.

·      To develop efficient methodologies to generate customized anti-tumor effecter T cells from human embryonic stem cells (hES) and induced pluripotent stem cells (iPS) by TCRengineering approach, University of Connecticut Health Center, Farmington, Arvind Chhabra, Principal Investigator, $200,000.00.

·      Generation of layer V pyramidal neurons from human embryonic stem cells, University of Connecticut, Storrs, Radmila Filipovic, Principal Investigator, $199,945.00.

·      Nuclear Receptor Control of Human Epidermal Stem Cells, University of Connecticut, Storrs, Brian J. Aneskievich, Ph.D., Principal Investigator, $199,894.00.

Back to questions