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 Connecticut Epidemiologist Newsletter   •   August 2021   •   Volume 41, No.5


Babesiosis Surveillance Connecticut, 2015–2019

Authors: A Bogacki MPH, J Sun MD PhD, J Mullins DVM MPH PhD, Epidemiology and Emerging Infections Program, Connecticut Department of Public Health.


Babesiosis is a tick-borne disease caused by microscopic parasites that infect red blood cells (1) and is the second most commonly reported tick-borne disease in Connecticut. Although there are over 100 species of tick-borne parasites that can cause babesiosis, Babesia microti is the most frequently found species in the United States that affects people. Babesiosis is primarily spread by the bite of an infected Ixodes scapularis, blacklegged tick; however, less commonly, B. microti can be transmitted through blood transfusion, and transplacentally from an infected mother to her baby during pregnancy or delivery (1,2). Most healthy individuals infected with B. microti are asymptomatic. Others can develop flu-like symptoms including fever, chills, sweats, myalgia, and weakness. It can be life threatening in the elderly, people who are immunocompromised or have serious underlying health conditions, and people without a spleen (asplenia). General laboratory findings include decreased hematocrit due to hemolytic anemia, and thrombocytopenia.

In Connecticut, the first cases of babesiosis were reported in 1988 (3). Babesiosis has been a physician reportable disease since 1989, and Babesia a laboratory reportable finding since 1990. In 2011, babesiosis became a nationally notifiable disease (4). The Connecticut Department of Public Health (DPH) uses the babesiosis national surveillance case definition, that combines laboratory, clinical, and epidemiologic information, to classify cases.

Due to the need for clinical information to determine case classification, DPH conducts follow up on all positive results meeting the national surveillance case definition laboratory criteria for diagnosis. Supplemental forms, and letters requesting full completion and return, are mailed to ordering providers and hospital Infection Control Practitioners.

During 2015–2019, the number of reports received annually by DPH increased 80% from 766 to 1380 (Figure). Follow up was conducted on 5260 reports with supportive or confirmatory laboratory results. Supplemental forms were returned for 3893 (74%) and included 1219 (31%) confirmed cases, 304 (8%) probable cases, and 2370 (61%) were classified as not a case (Figure). The remaining 1367 were classified as suspect. Further analyses were conducted by grouping confirmed and probable classifications for a total of 1523 cases.

Babesiosis incidence rates ranged from 6.9 (2018) to 9.2 (2015) cases per 100,000 population, with an annual average of 8.5 cases per 100,000 population. Windham and New London counties had the highest incidence and accounted for an annual average 36% of statewide cases.

Cases ranged from 0-98 years with 27% of cases occurring among those aged 60-69; 982 (65%) were male. Of the 1523 cases, race information was available for 1452 (96%) with 1170 (81%) White, 35 (2%) Black African American, 31 (2%) Asian, 22 (2%) Other, 3 (<1%) American Indian Alaskan Native, 3 (<1%) Native Hawaiian Pacific Islander, 188 (13%) Unknown. Ethnicity was available for 1425 (94%) cases; 96 (7%) identified as Hispanic/Latino, 1140 (80%) were non-Hispanic/Latino, and 189 (13%) unknown. Although cases were reported throughout the year, 80% were reported during the months of June–August.

The following signs and symptoms were reported among cases: 1088 (71%) fever, 847 (56%) myalgia, 782 (51%) thrombocytopenia, 742 (49%) chills, 727 (48%) headache, 712 (47%) anemia, 655 (43%) arthralgia, 496 (33%) sweats, and 260 (17%) had other conditions and most cases reported having multiple symptoms; 543 (36%) were hospitalized. The median hospital stay was 4 days (range: 1–37 days) and 4 (<1%) deaths were reported. In 2015, babesiosis was identified in two neonates (5).

The American Red Cross screens blood donations and reports donors identified to have a positive NAAT test for babesiosis. During 2015–2019, DPH received 421 reports of blood donors with positive Babesia screenings. Data linking blood donation to a case were not available as DPH did not receive any reports of confirmed or probable cases that were recipients of blood, organ, or tissue products, and no organ donors were identified (6). Blood donation was not reported from provider offices, which suggests this information was not available or not collected.


The total number of babesiosis reports received by DPH continues to increase annually and is likely due to receipt of more laboratory reports that do not meet the national case definition laboratory criteria for diagnosis. During 2011–2013, the average annual incidence rate for babesiosis was 6.2 cases per 100,000 population and in 2014, fell to 4.8 cases per 100,000 population. During 2015–2019, the average annual incidence rate increased to 8.5 cases per 100,000 population. Surveillance changes may have led to an increase in provider response rate, and subsequent increase in incidence. During 2015–2019, the rate of return for supplemental forms was 74%, versus just over 50% during 2011–2014.

When people are outdoors, steps should be taken to reduce the risk for babesiosis and other tick-borne diseases. Areas where ticks are commonly found, such as wooded and tall grassy areas, should be avoided if possible, especially during warmer months. Using personal protective clothing (i.e wearing long sleeve shirts and long pants to decrease the area of exposed skin) and tick repellents according to label instructions is also recommended for all persons when outdoors. It is critical to check for ticks on clothing and skin and to check pets for ticks when returning indoors.

Data show that babesiosis is underreported (7). Babesiosis is transmitted by the same tick species as Lyme disease and anaplasmosis. All three illnesses can cause general flu-like symptoms, share geographic locations, and peak during the summer months. When evaluating patients with flu-like symptoms suggestive of tick-borne illness, especially during the summer months, providers should consider ordering a tick-borne disease panel for purposes of differential diagnosis. DPH encourages providers to complete the necessary reporting forms for all tick-borne diseases, including the supplemental Babesiosis Case Report form and return it to DPH in a timely manner. Completed forms can be mailed to the CT Dept. of Public Health, 410 Capitol Avenue, MS#11EPI, PO Box 340308, Hartford CT, 06134-0308 in an envelope marked “Confidential” or faxed to 860-509-7910. Only one method of reporting is necessary.



  1. CDC. Babesiosis Information. Available at https://www.cdc.gov/parasites/babesiosis/ https://www.cdc.gov/parasites/babesiosis/. Assessed May 17, 2021.
  2. CDC. Babesiosis and the U.S. blood supply B. Available at https://www.cdc.gov/parasites/babesiosis/resources/babesiosis_policy_brief.pdf . Assessed on May 17, 2021.
  3. Gadbow JJ, Anderson JR, Cartter ML, et.al. Epidemiological Notes and Reports Babesiosis-Connecticut. 1989;38(38):649-650. Available at https://www.cdc.gov/mmwr/preview/mmwrhtml/00001468.htm. Accessed August 20, 2021. 
  4. CDC. Parasites-Babesiosis National Surveillance. Available at https://www.cdc.gov/parasites/babesiosis/surveillance.html. Assessed on July 19, 2021.
  5. Connecticut Department of Public Health. Babesiosis in Neonates-Connecticut 2015. Connecticut Epidemiologist. Vol. 36, No.4; September 2016. Available at https://portal.ct.gov/DPH/Epidemiology-and-Emerging-Infections/Connecticut-Epidemiologist-Newsletter-Archive-2010-2017. Assessed on May 26, 2021.
  6. Brennan M, Herwaldt B, Kazmierczak J, et. al. Transmission of Babesia microti Parasites by Solid Organ Transplantation. Emerging Infectious Diseases.  2016 Nov; 22(11): 1869–1876. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088010/. Assessed May 17, 2021.
  7. Diuk-Wasser M, Liu Y, Steeves T, et. al. Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA. Emerging Infectious Diseases. 2014 Feb; 20(2): 225–231. Available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901474/. Assessed on May 17, 2021.


Figure. Reported babesiosis cases in Connecticut, 2015–2019.

Figure of reported babesiosis cases in Connecticut, 2015-2019.








This page last updated 8/20/2021.