Have you checked your oil, water, brake fluid, and other fluid levels? Top them off, as needed.
A clean windshield and properly adjusted rearview mirrors are important for good visibility.
Make sure that all your lights and turn signals are working properly.
Check your tires carefully for tread wear or damage, and assure they are filled with the correct air pressure. Make sure your spare tire is road worthy.
Make sure you have safety devices like flares and/or reflective triangles to use in case you need them.
You may want to check with the National Weather Service for weather conditions on your planned routes.
Start your trip well-rested and alert. If you get tired along the way, take a break from driving.
The Department of Transportation has an Auto Safety Hotline: 1-888-DASH-2-DOT (1-888-327-4236) This service is provided by the National Highway Traffic Safety Administration of the U.S. Department of Transportation. For more information on safety issues, visit their web site at https://www.nhtsa.gov/about-nhtsa/contact-us
To obtain the latest traffic advisories and alerts when traveling, tune your car radio to 530 or 1610 on your AM dial.